The International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC) is a new-generation science and research centre focusing on finding new methods, technologies and medicines for effective prevention, early diagnostics and individualised treatment of cardiovascular and neurological diseases. The centre is based on the hospital’s successful, long-term cooperation with Mayo Clinic (USA) and other partners both in the Czech Republic and abroad. Areas of research at the FNUSA-ICRC include cardiovascular and transplant surgery, heart-failure treatment and transplant programmes, interventional cardiology and acute coronary syndromes, cardiac and central nervous system electrophysiology and pacing, cardiovascular and metabolic disorders, development of new methods and interventions to reduce risk factors, tissue engineering in cardiovascular research, cerebrovascular disease research, neuroepidemiology and several research platforms.